In situ encapsulation of biologically active ingredients into polymer particles by polymerization in dispersed media

The encapsulation of biologically active ingredients (e.g., peptides, proteins, enzymes, drugs) into polymer particles is extensively used for drug delivery purposes. However, this strategy relies mainly on emulsification processes from preformed polymers, which leads to strong limitations such as low particle concentrations (typically a few wt%), poor ingredient loadings, well rather limited structural diversity the polymers usually used. Conversely, polymerizations in dispersed media, allow formation scalable suspensions (nano)particles during polymerization process, have been advantageously situ ingredients. In review, ingredients, enzymes or drugs, obtained by media potential biomedical applications, covered. Their physical and chemical encapsulations were both considered function technique Several parameters will be discussed view adjusting loading efficiency agent considered.